(S)-4-(2-CARBOXY-PYRROLIDIN-1-YL)-PIPERIDINE-1-CARBOXYLIC ACID BENZYL ESTER
1-{1-[(benzyloxy)carbonyl]piperidin-4-yl}-L-proline
CAS: 289677-06-1
Molecular Formula: C18H24N2O4
(S)-4-(2-CARBOXY-PYRROLIDIN-1-YL)-PIPERIDINE-1-CARBOXYLIC ACID BENZYL ESTER - Names and Identifiers
| Name | 1-{1-[(benzyloxy)carbonyl]piperidin-4-yl}-L-proline |
| Synonyms | L-N-[(4 L-N-(4-N-CBZ-PIPERIDINO)PROLINE L-N-(4'-N-CBZ-PIPERIDINO)PROLINE L-N-(4'-N-Cbz-Piperidino)proline 1-{1-[(Benzyloxy)carbonyl]piperidin-4-yl}proline 1-{1-[(benzyloxy)carbonyl]piperidin-4-yl}proline 1-{1-[(Benzyloxy)carbonyl]piperidin-4-yl}-L-proline 1-{1-[(benzyloxy)carbonyl]piperidin-4-yl}-L-proline 4-(2-CARBOXY-PYRROLIDIN-1-YL)-PIPERIDINE-1-CARBOXYLIC ACID BENZYL ESTER (S)-1-(1-((Benzyloxy)carbonyl)piperidin-4-yl)pyrrolidine-2-carboxylic acid (S)-4-(2-CARBOXY-PYRROLIDIN-1-YL)-PIPERIDINE-1-CARBOXYLIC ACID BENZYL ESTER 1-piperidinecarboxylic acid, 4-(2-carboxy-1-pyrrolidinyl)-, 1-(phenylmethyl) ester 4-[(2S)-2-Carboxy-1-pyrrolidinyl]-1-piperidinecarboxylic acid 1-(phenylmethyl) ester 1-Piperidinecarboxylic acid, 4-[(2S)-2-carboxy-1-pyrrolidinyl]-, 1-(phenylmethyl) ester |
| CAS | 289677-06-1 |
| InChI | InChI=1/C18H24N2O4/c21-17(22)16-7-4-10-20(16)15-8-11-19(12-9-15)18(23)24-13-14-5-2-1-3-6-14/h1-3,5-6,15-16H,4,7-13H2,(H,21,22)/t16-/m0/s1 |
(S)-4-(2-CARBOXY-PYRROLIDIN-1-YL)-PIPERIDINE-1-CARBOXYLIC ACID BENZYL ESTER - Physico-chemical Properties
| Molecular Formula | C18H24N2O4 |
| Molar Mass | 332.39 |
| Density | 1.271 |
| Boling Point | 506.4±50.0 °C(Predicted) |
| Flash Point | 260°C |
| Vapor Presure | 4.48E-11mmHg at 25°C |
| pKa | 2.29±0.20(Predicted) |
| Storage Condition | 2-8°C |
| Refractive Index | 1.589 |
(S)-4-(2-CARBOXY-PYRROLIDIN-1-YL)-PIPERIDINE-1-CARBOXYLIC ACID BENZYL ESTER - Introduction
1-{1-[(benzyloxy)carbonyl]piperidin-4-yl}-L-proline is an organic compound whose chemical structure contains a piperidinyl group and a proline group. The following is a description of its nature, use, formulation and safety information:
Nature:
-Appearance: Usually a white crystalline solid.
-Solubility: Soluble in some organic solvents, such as methanol, ethanol and dimethyl sulfoxide.
-Melting point: Depending on the specific structure and crystal morphology, the melting point range is between 80-110 ° C.
Use:
1-{1-[(benzyloxy)carbonyl]piperidin-4-yl}-L-proline is widely used in the fields of organic synthesis and pharmaceutical research, and is often used as an intermediate for the synthesis of peptides and proteins. It can be used to construct peptide sequences with specific stereo configurations and functions for the research and development of new drug molecules.
Method:
1-{1-[(benzyloxy)carbonyl]piperidin-4-yl}-The preparation of L-proline generally involves the following steps:
1.4-piperidinecarboxylic acid reacts with 1-piperidinecarbonyl chloride to give 4 'piperidinyl urotropine.
2. Aromatic amine protection of 4 'piperidinyl urotropine using N-phenyl dichloroformamide.
3. Acyl peptidylation reaction was carried out under alkaline conditions to link the piperidinyl group protected by proline and aromatic amine.
Safety Information:
1-{1-[(benzyloxy)carbonyl]piperidin-4-yl}-The L-proline is not significantly dangerous under normal conditions of use. However, it is still a chemical substance and should be carried out following regular laboratory safe practice guidelines. Pay attention to protective measures, such as wearing appropriate personal protective equipment (such as gloves and goggles), and avoid contact with skin and eyes.
Nature:
-Appearance: Usually a white crystalline solid.
-Solubility: Soluble in some organic solvents, such as methanol, ethanol and dimethyl sulfoxide.
-Melting point: Depending on the specific structure and crystal morphology, the melting point range is between 80-110 ° C.
Use:
1-{1-[(benzyloxy)carbonyl]piperidin-4-yl}-L-proline is widely used in the fields of organic synthesis and pharmaceutical research, and is often used as an intermediate for the synthesis of peptides and proteins. It can be used to construct peptide sequences with specific stereo configurations and functions for the research and development of new drug molecules.
Method:
1-{1-[(benzyloxy)carbonyl]piperidin-4-yl}-The preparation of L-proline generally involves the following steps:
1.4-piperidinecarboxylic acid reacts with 1-piperidinecarbonyl chloride to give 4 'piperidinyl urotropine.
2. Aromatic amine protection of 4 'piperidinyl urotropine using N-phenyl dichloroformamide.
3. Acyl peptidylation reaction was carried out under alkaline conditions to link the piperidinyl group protected by proline and aromatic amine.
Safety Information:
1-{1-[(benzyloxy)carbonyl]piperidin-4-yl}-The L-proline is not significantly dangerous under normal conditions of use. However, it is still a chemical substance and should be carried out following regular laboratory safe practice guidelines. Pay attention to protective measures, such as wearing appropriate personal protective equipment (such as gloves and goggles), and avoid contact with skin and eyes.
Last Update：2024-04-09 20:45:29
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CAS: 289677-06-1
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CAS: 289677-06-1
Tel: 18301782025
Email: 3008007409@qq.com
Mobile: 18021002903
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